A deliberate approach to screening for initial crystallization conditions of biological macromolecules

Autor:	Christina K. Veatch, Robert J. Collins, Angela Lauricella, Joseph R. Luft, George T. DeTitta, Nancy A. Fehrman
Rok vydání:	2003
Předmět:	Materials science Computers business.industry Nanotechnology law.invention Automation Biopolymers Structural Biology Casting (metalworking) law Crystallization Process engineering business Oils Software Macromolecule
Zdroj:	Journal of Structural Biology. 142:170-179
ISSN:	1047-8477
Popis:	A method to rationally predict crystallization conditions for a previously uncrystallized macromolecule has not yet been developed. One way around this problem is to determine initial crystallization conditions by casting a wide net, surveying a large number of chemical and physical conditions to locate crystallization leads. A facility that executes the rapid survey of crystallization lead conditions is described in detail. Results and guidelines for the initial screening of crystallization conditions, applicable to both manual and robotic setups, are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b24a6f9c64b16c12da4f3781d1dfe4 https://doi.org/10.1016/s1047-8477(03)00048-0 Zobrazit plný text záznamu Full Text from ScienceDirect