Separation of Anti-inflammatory and Immunosuppressive Activities in Heterologous Antilymphocyte Serum
| Autor: | R. J. Perper, E. M. Glenn, R. E. Monovich |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Antiserum
Multidisciplinary Graft rejection medicine.drug_class Chemistry Immune Sera Anti-Inflammatory Agents Heterologous Skin Transplantation Anti-inflammatory Humoral antibody Mechanism of action Transplantation Immunology Antibody Formation Immunology medicine Lymphocytes medicine.symptom Immunosuppressive Agents Antilymphocyte Serum |
| Zdroj: | Nature. 223:86-87 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | HETEROLOGOUS antilymphocyte serum (ALS) has both anti-inflammatory and immunosuppressive properties1. Although ALS significantly suppresses graft rejection, its suppression of humoral antibody formation is more variable and often less effective2. Because non-immunosuppressive anti-inflammatory agents can delay graft rejection3,4, it seemed important to determine if ALS delays graft rejection by primarily anti-inflammatory or immunosuppressive, or a combination of both mechanisms. In addition, an analysis of methods by which these activities may be separately induced should provide insight into the mechanism of action and specificity of the antisera. |
| Databáze: | OpenAIRE |
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