Intracellular Ion Control of WNK Signaling

Autor:	Elizabeth J, Goldsmith, Aylin R, Rodan
Rok vydání:	2023
Předmět:	Physiology
Zdroj:	Annual Review of Physiology. 85:383-406
ISSN:	1545-1585 0066-4278
Popis:	The with no lysine (K) (WNK) kinases are an evolutionarily ancient group of kinases with atypical placement of the catalytic lysine and diverse physiological roles. Recent studies have shown that WNKs are directly regulated by chloride, potassium, and osmotic pressure. Here, we review the discovery of WNKs as chloride-sensitive kinases and discuss physiological contexts in which chloride regulation of WNKs has been demonstrated. These include the kidney, pancreatic duct, neurons, and inflammatory cells. We discuss the interdependent relationship of osmotic pressure and intracellular chloride in cell volume regulation. We review the recent demonstration of potassium regulation of WNKs and speculate on possible physiological roles. Finally, structural and mechanistic aspects of intracellular ion and osmotic pressure regulation of WNKs are discussed. Expected final online publication date for the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ac67dad3570d9d5c2ad107dfb639e1 https://doi.org/10.1146/annurev-physiol-031522-080651 Zobrazit plný text záznamu