Tbr1 instructs laminar patterning of retinal ganglion cell dendrites
| Autor: | John L.R. Rubenstein, Arjun Krishnaswamy, Bin Chen, Jasmine D.S. Reggiani, Mallory A. Laboulaye, Joshua R. Sanes, Jinyue Liu, Shristi Pandey |
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| Rok vydání: | 2018 |
| Předmět: |
Retinal Ganglion Cells
0301 basic medicine Cell type genetic structures Neurite Receptors Cell Surface Nerve Tissue Proteins Retinal ganglion Article Mice 03 medical and health sciences Interneurons Pregnancy Receptors Neurites medicine Animals Psychology Calcium Signaling Transcription factor Neurology & Neurosurgery biology Gene Expression Profiling General Neuroscience Neurosciences Dendrites Cadherins Inner plexiform layer eye diseases Transmembrane protein DNA-Binding Proteins Electroporation 030104 developmental biology medicine.anatomical_structure Retinal ganglion cell Cell Surface biology.protein Female Cognitive Sciences sense organs TBR1 T-Box Domain Proteins Neuroscience |
| Zdroj: | Nature neuroscience, vol 21, iss 5 Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendritic restriction arises is unclear. We show that the transcription factor Tbr1 is expressed by four mouse RGC types with dendrites in the outer IPL, and is required for their laminar specification. Loss of Tbr1 results in elaboration of dendrites within the inner IPL, while mis-expression in other cells re-targets their neurites to the outer IPL. Two transmembrane molecules, Sorcs3 and Cdh8, act as effectors of the Tbr1-controlled lamination program. However, they are expressed in just one Tbr1-expressing RGC type, supporting a model in which a single transcription factor implements similar laminar choices in distinct cell types by recruiting partially non-overlapping effectors. |
| Databáze: | OpenAIRE |
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