Sex-biased patterns shaped the genetic history of Roma

Autor: Horolma Pamjav, Halyna Makukh, Mihai G. Netea, Carla García-Fernández, Begoña Dobon, Francesc Calafell, Neus Font-Porterias, Vaidutis Kučinskas, David Comas, E. Sukarova-Stefanovska, Jaume Bertranpetit
Přispěvatelé: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya
Rok vydání: 2019
Předmět:
0106 biological sciences
0301 basic medicine
Gene Flow
Male
Lineage (genetic)
Roma
Human Migration
Population
Ethnic group
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
lcsh:Medicine
010603 evolutionary biology
01 natural sciences
DNA
Mitochondrial
Article
White People
Gene flow
03 medical and health sciences
Asian People
Genetic variation
Ethnicity
Humans
lcsh:Science
education
Author Correction
History
Ancient
education.field_of_study
Sex Characteristics
Multidisciplinary
Chromosomes
Human
Y
Human migration
business.industry
lcsh:R
Genetic Variation
Founder Effect
030104 developmental biology
Geography
Genetics
Population
Haplotypes
Evolutionary biology
lcsh:Q
Female
Gene pool
business
Human mitichondrial DNA
haplogroup-H
populations
Founder effect
Zdroj: Scientific Reports
Scientific Reports, 10, 1
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, 10
Scientific reports, Berlin : Nature Research, 2020, vol. 10, iss. 1, art. no. 14464, p. [1-10]
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
ISSN: 2045-2322
Popis: The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time.
Tis work was supported by the Spanish Ministry of Economy and Competitiveness (grant numbers CGL2016- 75389-P (MINEICO/FEDER, UE), PID2019-106485GB-I00 (MINEICO), and “Unidad María de Maeztu” (MDM-2014-0370) to DC and FC; and Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya, grant 2017SGR00702). NF-P was supported by a FPU17/03501 fellowship
Databáze: OpenAIRE
Externí odkaz: