Few-Layer Bismuthene for Checkpoint Knockdown Enhanced Cancer Immunotherapy with Rapid Clearance and Sequentially Triggered One-for-All Strategy
| Autor: | Xu Zhang, Mengyu Guo, Ru Bai, Jing Liu, Zhanjun Gu, Ying Liu, Yaling Wang, Fene Gao, Xiaolei Zhang, Bo Li, Chunying Chen, Xuhao Hu, Jiayang Li, Xiao Zhang, Huige Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
Gene knockdown
Chemistry medicine.medical_treatment General Engineering General Physics and Astronomy Immunotherapy Photothermal therapy Immune checkpoint Blockade Lymphocytes Tumor-Infiltrating Cancer immunotherapy In vivo Neoplasms Toxicity medicine Cancer research Humans General Materials Science |
| Zdroj: | ACS Nano. 14:15700-15713 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.0c06656 |
| Popis: | As a conceptually attractive strategy, the use of immune checkpoint blockade antibodies to treat cancer is limited due to the restrained tumor-infiltrating lymphocytes (TILs), poor accumulation and penetration of antibodies, and deficient checkpoint blockade in malignancies. In this study, we describe a pH and mild photothermal sequentially triggered PD-L1 siRNA release nanosystem, based on monoelemental bismuthene, as a one-for-all strategy to realize enhanced tumor mild photothermal immunotherapy. Under manually controlled NIR irradiation, the bismuthene-based nanosystem simultaneously induces a tumor-enhanced pathological permeability and retention (EPPR) effect, increases TIL recruitment, and triggers programmed siRNA release, thereby amplifying anti-PD-L1 immunotherapy. In addition, the nanosystem's rapid removal through intestinal and renal clearance mitigates toxicity risk associated with long-term retention. In vivo antitumor experiments demonstrate that this bismuthene-based nanosystem is a promising and effective approach for "cold" tumor management. |
| Databáze: | OpenAIRE |
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