Role of Low-Dose Computerized Tomography in Lung Cancer Screening among Never-Smokers
| Autor: | Hye Rin Kang, Jun Yeun Cho, Kyung Won Lee, Sang Hoon Lee, Ho Il Yoon, Choon Taek Lee, Young Jae Cho, Jae Ho Lee, Jongsun Park, Yeon Joo Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Population Adenocarcinoma of Lung Radiation Dosage 03 medical and health sciences 0302 clinical medicine Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans education Lung cancer Early Detection of Cancer Aged Retrospective Studies education.field_of_study Lung business.industry Incidence Smoking Cancer Retrospective cohort study Middle Aged respiratory system Prognosis medicine.disease Small Cell Lung Carcinoma respiratory tract diseases Survival Rate 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Carcinoma Large Cell Adenocarcinoma Female National Lung Screening Trial Tomography X-Ray Computed business Lung cancer screening Follow-Up Studies |
| Zdroj: | Journal of Thoracic Oncology. 14:436-444 |
| ISSN: | 1556-0864 |
| Popis: | Introduction The incidence of lung cancer among never-smokers has been increasing rapidly. The U. S. National Lung Screening Trial and the NELSON trial showed that screening using low-dose computerized tomography (LDCT) effectively reduced lung cancer mortality among heavy smokers. However, its effectiveness in never-smokers has not been well investigated. This study investigated the role of LDCT in lung cancer screening among never-smokers. Methods The study was designed as a single-center, retrospective cohort study. We analyzed the data on patients who underwent LDCT screening between May 2003 and June 2016. Nodules detected by computerized tomography were classified according to the Lung Imaging Reporting and Data System criteria. The detection rate and lung cancer outcomes (type of cancer, staging of lung cancer, and mortality) according to smoking history were determined. Results Of the 28,807 enrolled patients, 12,176 were never-smokers; of these patients, 7744 (63.6%) were women and 1218 (10.0%) were found to have lung nodules. Overall, lung cancer was diagnosed in 55 never-smokers (0.45%). In contrast, lung cancer was diagnosed in 143 (0.86%) of the 16,631 ever-smokers. Of the never-smokers with lung cancer, 51 (92.7%) presented with stage I disease, and all patients had adenocarcinomas. Conclusions In the never-smoker population, LDCT screening helped to detect a significant number of lung cancers. Most of these lung cancers were detected at a very early stage. The positive results of the National Lung Screening Trial in the United States and the NELSON trial may have established the value of LDCT screening for heavy smokers, but future research should consider the value of using LDCT screening in the never-smoker population. |
| Databáze: | OpenAIRE |
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