High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients
| Autor: | Karem Miléo Felício, Fabrício de Souza Resende, Márcia Costa Dos Santos, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Ana Regina Bastos Motta, Pedro Paulo Freire Piani, Maria Clara Neres Iunes de Oliveira, Isabel Jane Campos Lobato, João Soares Felício, Norberto Jorge Kzan de Souza Neto, Luísa Corrêa Janaú, Natércia Neves Marques de Queiroz, Lorena Vilhena de Moraes, Ícaro José Araújo de Souza, Melissa de Sá Oliveira Dos Reis, Ana Carolina Contente Braga de Souza, Manuela Nascimento de Lemos, Apolone da Mota Queiroz, Lilian de Souza D’Albuquerque Silva, Angélica Leite de Alcântara, Priscila Boaventura Barbosa de Figueiredo, Nivin Mazen Said |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Endocrinology Diabetes and Metabolism Diastole Blood Pressure 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus medicine Vitamin D and neurology Humans Cholecalciferol Morning business.industry Blood Pressure Monitoring Ambulatory Vitamin D Deficiency medicine.disease Blood pressure chemistry Dietary Supplements Glycated hemoglobin business |
| Zdroj: | Current Diabetes Reviews. 17:378-386 |
| ISSN: | 1573-3998 |
| DOI: | 10.2174/1573399816999200729131508 |
| Popis: | Background: Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. The effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial. Objective: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive patients with diabetes mellitus 1 (DM1) patients by 24-hour ambulatory blood pressure monitoring (ABPM). Methods: We performed a clinical trial including 35 DM1 normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation. Results: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p Conclusion: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive DM1 patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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