Galectin-3: a new biomarker for differentiating periodic fever, adenitis, pharyngitis, aphthous stomatitis (PFAPA) syndrome from familial Mediterranean fever?
| Autor: | Ezgi Deniz Batu, Selcan Demir, Seza Ozen, Emine Vezir, Gizem Akpınar, Elmas Öğüş, Özlem Özbaş Demirel |
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| Rok vydání: | 2021 |
| Předmět: |
Male
PFAPA syndrome medicine.medical_specialty Adolescent Galectin 3 Immunology Familial Mediterranean fever Enzyme-Linked Immunosorbent Assay Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Lymphadenitis Internal medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Child Stomatitis 030203 arthritis & rheumatology business.industry Infant Newborn Infant Pharyngitis Adenitis Syndrome medicine.disease Familial Mediterranean Fever Cross-Sectional Studies Galectin-3 Case-Control Studies Child Preschool Biomarker (medicine) Female Stomatitis Aphthous medicine.symptom business Biomarkers |
| Zdroj: | Rheumatology international. 42(1) |
| ISSN: | 1437-160X |
| Popis: | Differentiating PFAPA (periodic fever, aphthosis, pharyngitis, and adenitis) syndrome from familial Mediterranean fever (FMF) could be challenging in some cases. Galectin-3 is a lectin with regulatory functions in apoptosis and inflammation. We aimed to test whether galectin-3 could be a biomarker for differentiating PFAPA syndrome from FMF. Patients with PFAPA syndrome, FMF, cryopyrin-associated periodic syndrome (CAPS), and streptococcal pharyngitis, and healthy controls were included in this study. Serum galectin-3 levels were measured using enzyme-linked immunosorbent assay. Eighty-seven patients (36 with PFAPA, 39 with FMF, 8 with CAPS, 4 with streptococcal pharyngitis), and 17 healthy controls were included. Blood samples were drawn during attacks from 20 PFAPA and 7 FMF patients and attack-free periods from 22 PFAPA, 35 FMF, and 8 CAPS patients. The median serum galectin-3 level in the PFAPA-attack group (1.025 ng/ml) was significantly lower than the levels in healthy control (2.367 ng/ml), streptococcal pharyngitis (3.021 ng/ml), FMF attack (2.402 ng/ml), and FMF-attack-free groups (2.797 ng/ml) (p = 0.006, 0.03, 0.01, and |
| Databáze: | OpenAIRE |
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