| Autor: |
Kavita Pal, Md Kausar Raza, Jenny Legac, Abdur Rahman, Shoaib Manzoor, Souvik Bhattacharjee, Philip J. Rosenthal, Nasimul Hoda |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
European journal of medicinal chemistry. 248 |
| ISSN: |
1768-3254 |
| Popis: |
Malaria is the most lethal parasitic infections in the world. To address the emergence of drug resistance to current antimalarials, here we report the design and synthesis of new series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide hybrids by using multicomponent Petasis reaction as the key step and evaluated in vitro for their antimalarial effectiveness. The structure of all the compounds were confirmed by NMR Spectroscopy and mass spectrometry. Most of the compounds showed potent antimalarial activity against both CQ-sensitive (3D7) and CQ-resistant (W2) strains. A8, A5, and A4 are the most potent compounds that showed excellent anti-plasmodial activity against CQ-resistant strain in the nanomolar range with IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect