Protective Effect of Theaflavin on Erythrocytes Subjected toIn VitroOxidative Stress
| Autor: | Syed Ibrahim Rizvi, Krishna Misra, Mahejabeen Fatima, Rajesh Kumar Kesharwani |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
Article Subject Traditional medicine business.industry medicine.medical_treatment Glutathione Pharmacology Malondialdehyde medicine.disease_cause Biochemistry Redox In vitro lcsh:Biochemistry chemistry.chemical_compound chemistry medicine lcsh:QD415-436 Theaflavin business Intracellular Oxidative stress Research Article |
| Zdroj: | Biochemistry Research International Biochemistry Research International, Vol 2013 (2013) |
| ISSN: | 2090-2255 2090-2247 |
| Popis: | Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report thein vitroeffect of theaflavins on erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), and plasma membrane redox system (PMRS) of rats. The effect of theaflavin on PMRS has also been validated through anin silicodocking simulation study using Molegro Virtual Docker (MVD). We report that theaflavins show significant protection to erythrocyte against oxidative stress induced bytert-butyl hydroperoxide (t-BHP). The findings suggest a possible protective role of theaflavins as antioxidant. |
| Databáze: | OpenAIRE |
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