Impact of Treatment Beyond Progression with Immune Checkpoint Blockade in Hodgkin Lymphoma
| Autor: | James Godfrey, Pallawi Torka, Sonali M. Smith, Suman Paul, Madelyn Burkart, Raoul Santiago, Robert T. Chen, Ranjana H. Advani, Frederick Lansigan, Alex F. Herrera, Catherine Wei, Julio C. Chavez, Sarit Assouline, Reem Karmali, Kevin A. David, N Nina Wagner-Johnston, Catherine Diefenbach, Jakub Svoboda, Steven M. Bair, Sarah Tomassetti, Yang Liu, Daniel O. Persky, Lukas Emery, Sunita Nathan, Reid W. Merryman, Nicole A. Carreau, Muhammad Hamid, Andrea B. Troxel, Philippe Armand, Stefan K. Barta, Radhakrishnan Ramchandren, Jonathan B. Cohen, Michael A. Spinner |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Treatment failure Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Retrospective analysis Humans Immune Checkpoint Inhibitors Retrospective Studies business.industry Retrospective cohort study Hodgkin Disease Immune checkpoint Blockade Treatment Outcome 030104 developmental biology 030220 oncology & carcinogenesis Cohort Hodgkin lymphoma Brief Communications business Cohort study |
| Zdroj: | Oncologist |
| ISSN: | 1549-490X 1083-7159 |
| Popis: | Atypical response patterns following immune checkpoint blockade (ICB) in Hodgkin lymphoma (HL) led to the concept of continuation of treatment beyond progression (TBP); however, the longitudinal benefit of this approach is unclear. We therefore performed a retrospective analysis of 64 patients treated with ICB; 20 who received TBP (TBP cohort) and 44 who stopped ICB at initial progression (non-TBP cohort). The TBP cohort received ICB for a median of 4.7 months after initial progression and delayed subsequent treatment by a median of 6.6 months. Despite receiving more prior lines of therapy, the TBP cohort achieved longer progression-free survival with post-ICB treatment (median, 17.5 months vs. 6.1 months, p = .035) and longer time-to-subsequent treatment failure, defined as time from initial ICB progression to failure of subsequent treatment (median, 34.6 months vs. 9.9 months, p = .003). With the limitations of a retrospective study, these results support the clinical benefit of TBP with ICB for selected patients. |
| Databáze: | OpenAIRE |
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