Human blood test based on surface-enhanced Raman spectroscopy technology using different excitation light for nasopharyngeal cancer detection
| Autor: | Joseph Tung-Chieh Chang, Huijing Lin, Rong Chen, Jiahui Zhou, Weiwei Chen, Tsung-Min Hung, Qiong Wu, Jianji Pan, Yun Yu, Sufang Qiu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Materials science 02 engineering and technology 010402 general chemistry Spectrum Analysis Raman 01 natural sciences Sensitivity and Specificity Spectral line Nuclear magnetic resonance medicine Humans Statistical analysis Electrical and Electronic Engineering Spectral data Excitation wavelength Squamous Cell Carcinoma of Head and Neck Nasopharyngeal Neoplasms Surface-enhanced Raman spectroscopy Middle Aged 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Electronic Optical and Magnetic Materials Wavelength Nasopharyngeal carcinoma Case-Control Studies Multivariate Analysis 0210 nano-technology Excitation Biotechnology Research Article |
| Zdroj: | IET Nanobiotechnol |
| ISSN: | 1751-875X |
| Popis: | Nasopharyngeal carcinoma (NPC), a kind of squamous cell carcinoma, occurs in the top and the side wall of nasopharyngeal, which harms human health and life. In this study, a novel blood test (SERS) was carried out for 30 NPC patients and 30 normal ones. Using multi-variate statistical analysis for spectral data, the diagnostic sensitivities of 89.3% (50/56) and 85.7% (48/56) can be achieved for 633 and 785 nm exciting wavelength, respectively. Also corresponding specificities are 71.4% (41/56) and 78.6% (44/56), respectively. These results demonstrated that the two kinds of excitation wavelength all have the feasibility of obtaining high-quality SERS spectra to differentiate cancer from normal samples. Furthermore, the performance of the SERS test with 785 nm wavelength excitation is nearly equal to the SERS experimental effect under 633 nm wavelength excitation for NPC detection. |
| Databáze: | OpenAIRE |
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