Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease
| Autor: | Yu Hyeon Choi, Hee Young Ju, Hee Young Shin, Hyo Seop Ahn, June Dong Park, Hyoung Jin Kang, Hyery Kim, Ji Won Lee, Bongjin Lee, Dong In Suh, Che Ry Hong, Kyung Duk Park, Hyeong Jin Lee, Hyung Joo Jeong |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Drug
Male medicine.medical_specialty Antifungal Agents Time Factors Adolescent Itraconazole media_common.quotation_subject hypotensive drug Pharmaceutical Science Blood Pressure Disease CRRT Risk Factors Drug Discovery Republic of Korea Odds Ratio Medicine Humans Adverse effect Child media_common Original Research Retrospective Studies Pharmacology Drug Design Development and Therapy business.industry Incidence Age Factors inotropics Infant Retrospective cohort study Odds ratio hemato-oncologic disease medicine.disease Surgery itraconazole Blood pressure Mycoses Anesthesia Child Preschool Hematologic Neoplasms Linear Models Administration Intravenous Female Hypotension business Febrile neutropenia medicine.drug |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| Popis: | Hyeong Jin Lee,1,* Bongjin Lee,2,* June Dong Park,2 Hyung Joo Jeong,2 Yu Hyeon Choi,2 Hee Young Ju,1 Che Ry Hong,1 Ji Won Lee,1 Hyery Kim,1 Dong In Suh,3 Kyung Duk Park,1 Hyoung Jin Kang,1 Hee Young Shin,1 Hyo Seop Ahn1 1Department of Pediatrics, Cancer Research Institute, 2Division of Pediatric Intensive Care, Department of Pediatrics, 3Division of Pulmonology, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea *These authors contributed equally tothis work Purpose: Although few adverse effects have been reported for itraconazole, a widely used antifungal therapy for febrile neutropenia, we found intravenous (IV) itraconazole to be associated with serious cases of blood pressure (BP) drop. We therefore evaluated the incidence and risk factors for BP drop during IV administration of the drug.Materials and methods: We reviewed the medical records of children with hemato-oncologic disease who were treated with IV itraconazole from January 2012 to December 2013. By analyzing systolic BP (SBP) measurements made from 4 hours before through to 4 hours after itraconazole administration, we evaluated the changes in SBP and the risk factors for an SBP drop, especially clinically meaningful (≥20%) drops.Results: Itraconazole was administered 2,627 times to 180 patients. The SBP during the 4 hours following itraconazole administration was lower than during the 4 hours before administration (104 [53.0–160.33 mmHg] versus 105 [59.8–148.3 mmHg]; P |
| Databáze: | OpenAIRE |
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