New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2'-deoxyribosyltransferases
| Autor: | Javier Acosta, Jesús Fernández-Lucas, Jon Del Arco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biocatálisis
0106 biological sciences Chemical process Active ingredient Biotecnología 0303 health sciences Engineering Biología molecular Drug Industry Industria farmacéutica business.industry Bioengineering Context (language use) Nucleosides 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences Pharmaceutical Preparations 010608 biotechnology Biocatalysis Biochemical engineering business 030304 developmental biology Biotechnology Pharmaceutical industry |
| Zdroj: | Biotechnology advances. 51 |
| ISSN: | 1873-1899 |
| Popis: | Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole-cell mediated processes offer an efficient, sustainable and cost-effective alternative to the traditional multi-step and environmentally-harmful chemical processes. Particularly, 2'-deoxyribosyltransferases (NDTs) have emerged as a novel synthetic alternative, not only to chemical but also to other enzyme-mediated synthetic processes. This review describes recent findings in the development and scaling up of NDTs as industrial biocatalysts, including the most relevant and recent examples of single enzymatic steps, multienzyme cascades, chemo-enzymatic approaches, and engineered biocatalysts. Finally, to reflect the inventive and innovative steps of NDT-mediated bioprocesses, a detailed analysis of recently granted patents, with specific focus on industrial synthesis of nucleoside-based APIs, is hereunder presented. Sin financiación 17.681 Q1 JCR 2021 2.482 Q1 SJR 2021 No data IDR 2021 UEM |
| Databáze: | OpenAIRE |
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