Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices
Autor: | Riyadh A Alsakeni, Marwan S.M. Al-Nimer, Talar Ahmad Merza Mohammad |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Fibromyalgia Revised Fibromyalgia Impact Questionnaire lcsh:Medicine Newly diagnosed 03 medical and health sciences 0302 clinical medicine Internal medicine platelet activation Medicine Platelet activation Mean platelet volume 030203 arthritis & rheumatology Platelet indices mean platelet volume business.industry lcsh:R General Medicine medicine.disease serotonin Biomarker (medicine) Original Article Serotonin business 030217 neurology & neurosurgery |
Zdroj: | Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences Journal of Research in Medical Sciences, Vol 23, Iss 1, Pp 71-71 (2018) |
ISSN: | 1735-7136 1735-1995 |
Popis: | Background: This study aimed to assess the serum serotonin levels in the newly diagnosed fibromyalgia (FM) and to relate these levels to the presenting signs and symptoms. Materials and Methods: This case–control study included 35 healthy women (Group I) served as controls and 130 women with newly diagnosed FM (Group II). The diagnosis of FM was confirmed by the diagnostic criteria of the American College of Rheumatology-10. The assessment of pain using a revised fibromyalgia impact questionnaire and tender points scoring, blood platelet indices, and serum serotonin levels were determined. Results: Group II patients had significantly (P < 0.001) higher values of mean platelet volume (MPV) (10.60 ± 1.57fL) and platelet width distribution (16.25 ± 1.45%) than the corresponding values in Group I (8.73 ± 0.81fL and 15.0 ± 1.15%). Significant low-serum serotonin levels observed in Group II patients compared with Group I healthy individuals (187.3 ± 50.3 ng/ml vs. 219.5 ± 78.3 ng/ml, P = 0.026). Multiple linear regression analysis showed the nonsignificant correlations between serum serotonin levels and platelet indices in Group II patients. Conclusion: Newly diagnosed FM women have significantly low-serum serotonin levels, which does not correlate with a significant increment of the platelet activity expressed as increase MPV and platelet width distribution percentage. Therefore, this study highlighted that the correction of serum serotonin level by medicines could help the patients. |
Databáze: | OpenAIRE |
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