Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: Case report and review of the literature
| Autor: | Kaaren K. Reichard, David S. Viswanatha, John Hozier, Qian-Yun Zhang, Kathryn Foucar, Lorraine Sanchez |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Chromosomal translocation Human leukocyte antigen Precursor T-Cell Lymphoblastic Leukemia-Lymphoma hemic and lymphatic diseases Acute lymphocytic leukemia Internal medicine Living Donors Chromosomes Human Humans Transplantation Homologous Medicine In Situ Hybridization Fluorescence Bone Marrow Transplantation Chromosome Aberrations Transplantation Chimera Hematology business.industry Myeloid leukemia Neoplasms Second Primary Karyotype medicine.disease Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Karyotyping Immunology Female Bone marrow business |
| Zdroj: | American Journal of Hematology. 81:178-185 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.20389 |
| Popis: | We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor T-cell acute lymphoblastic -leukemia (T-ALL). The cells for BMT were from his human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after allogeneic BMT is a rare, yet well-documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature. |
| Databáze: | OpenAIRE |
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