Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system
Autor: | Mengjie Tang, Weinan Pan, Wei Liu, Jialong Yan |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Vascular smooth muscle business.industry Angiogenesis Vasodilation General Medicine Review Article 030204 cardiovascular system & hematology medicine.disease Pulmonary hypertension Apelin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Vasculogenesis Internal medicine Heart failure Renin–angiotensin system Cardiology Medicine business |
Popis: | Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular system of fetuse and adult. The signal is involved in the development of the fetal heart and blood vessels and regulating vascular tension in adults. This review described the effects of apelin/ELA-APJ on fetal (vasculogenesis and angiogenesis) and adult cardiovascular function [vascular smooth muscle cell (VSMC) proliferation, vasodilation, positive myodynamia], and relative diseases [eclampsia, hypertension, pulmonary hypertension, heart failure (HF), myocardial infarction (MI), atherosclerosis, etc.] in detail. The pathways of apelin/ELA-APJ regulating cardiovascular function and cardiovascular-related diseases are summarized. The drugs developed based on apelin and ELA suggests APJ is a prospective strategy for cardiovascular disease therapy. |
Databáze: | OpenAIRE |
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