Icotidine, an antagonist of histamine at both H1 and H2 receptors
| Autor: | Robert Blakemore, G. J. Durant, D. A. A. Owen, Charon R. Ganellin, Thomas Henry Brown, C. A. Harvey, Michael E. Parsons, A. C. Rasmussen, G. S. Sach, D. G. Cooper, Robert John Ife |
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| Rok vydání: | 1986 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemical Phenomena Pyridines Bronchi Histamine H1 receptor Pharmacology In Vitro Techniques Gastric Acid chemistry.chemical_compound Histamine receptor Structure-Activity Relationship Histamine H2 receptor Immunology and Allergy Medicine Animals Humans Histamine H4 receptor business.industry Antagonist Imidazoles Heart General Medicine Chemistry chemistry Histamine H2 Antagonists Competitive antagonist Histamine H1 Antagonists Vascular Resistance Histamine H3 receptor business Histamine |
| Zdroj: | New England and regional allergy proceedings. 7(2) |
| ISSN: | 0742-2814 |
| Popis: | SK&F 93319 (icotidine), 2-[4-(3-methoxypyrid-2-yl)butylamino]-5-[(6-methylpyrid-3-yl )-methyl]- pyrimidin-4-one trihydrochloride, has been identified as a novel agent which combines into one molecule the ability to antagonize the actions of histamine at H1 and H2 receptors across a similar concentration or dose range. The degree of antagonism of vascular responses to histamine exceeds that possible with either an H1- or H2-receptor histamine antagonist alone. SK&F 93319 may have therapeutic utility in conditions requiring simultaneous antagonism of histamine at H1 and H2 receptors. |
| Databáze: | OpenAIRE |
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