Elevated CA-125 Level and ER-Negative as Prognostic Factors for Ovarian Metastasis in Patients with Endometrial Cancer: A Retrospective Cohort Study
| Autor: | Yangyang Li, Hui Zhou, Zheyu Zheng, Jing Xu, Jinxiao Liang, Xiaoting Ling, Huaiwu Lu, Guocai Xu, Zhongqiu Lin |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Ovariectomy medicine.medical_treatment Estrogen receptor Risk Factors Clinical Research Internal medicine medicine Humans Neoplasm Metastasis Risk factor Retrospective Studies Ovarian Neoplasms Univariate analysis Hysterectomy business.industry Incidence (epidemiology) Endometrial cancer Oophorectomy Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Endometrial Neoplasms ROC Curve Receptors Estrogen CA-125 Antigen Multivariate Analysis Female Receptors Progesterone business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.928826 |
| Popis: | BACKGROUND The utility of cancer antigen 125 (CA-125), estrogen receptor (ER), and progesterone receptor (PR) in evaluation for ovarian metastasis of endometrial cancer has yet to be determined. The purpose of this study was to investigate the incidence and the possible risk factors of ovarian metastasis. MATERIAL AND METHODS A retrospective study was performed in endometrial cancer patients who accepted surgical intervention of hysterectomy and oophorectomy during 2002-2013 in Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. Clinico-pathologic characteristics and the possible risk factors were investigated. RESULTS A total of 565 patients were identified, of which 5.7% had ovarian metastasis. Univariate analysis and multivariate analysis revealed that deeper myometrial invasion, tubal involvement, and parametrial involvement were independent risk factors. In subgroup analysis, univariate analysis showed that elevated CA-125 level and negative ER were associated with ovarian metastasis (P |
| Databáze: | OpenAIRE |
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