'Test n Treat' (TnT) : a cluster randomized feasibility trial of on-site rapid 'Chlamydia trachomatis' tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges

Autor: Vari Drennan, Syed Tariq Sadiq, Tim Planche, Elisabeth J Adams, Rachel Phillips, Alastair Green, Emma Cousins, Charlotte Fleming, Pippa Oakeshott, Fiona Reid, Wendy Majewska, Emma M. Harding-Esch, Sarah Kerry-Barnard, R.I. Bartholomew
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Cluster randomised
Gonorrhea
Rapid tests
Chlamydia trachomatis
medicine.disease_cause
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
London
Ethnicity
Prevalence
030212 general & internal medicine
Test and treat
WOMEN
EDUCATION
General Medicine
Sexual Partners
Infectious Diseases
Screening
Female
Young people
GONORRHEA
Life Sciences & Biomedicine
Cluster randomized
Diagnostic Screening Programs
Microbiology (medical)
medicine.medical_specialty
Adolescent
Sexual Behavior
030106 microbiology
Sexually Transmitted Diseases
Time to treatment
alliedhealth
Rapid C. trachomatis tests
Sex education
Microbiology
Time-to-Treatment
Young Adult
03 medical and health sciences
Sexually active
PEOPLE
Feasibility trial
Internal medicine
TRANSMITTED INFECTIONS
medicine
Humans
ATTITUDES
Students
Trial registration
Science & Technology
Technical colleges
business.industry
1103 Clinical Sciences
CARE
Chlamydia Infections
Ethnically diverse
medicine.disease
Median time
SETTINGS
Feasibility Studies
business
POINT
Zdroj: Oakeshott, P, Kerry-Barnard, S, Fleming, C, Phillips, R, Drennan, V M, Adams, E J, Majewska, W, Harding-Esch, E M, Cousins, E C, Planche, T, Green, A, Bartholomew, R I, Tariq Sadiq, S & Reid, F 2019, ' “Test n Treat” (TnT) : a cluster randomised feasibility trial of on-site rapid Chlamydia trachomatis tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges ', CLINICAL MICROBIOLOGY AND INFECTION, vol. 25, no. 7, pp. 865-871 . https://doi.org/10.1016/j.cmi.2018.10.019
ISSN: 5803-8795
1198-743X
1469-0691
Popis: Objectives\ud We conducted a cluster-randomized feasibility trial of 90-minute Chlamydia trachomatis tests and same day on-site treatment (‘Test n Treat/TnT’) in six technical colleges in London, England, to assess TnT uptake rates; follow-up rates; prevalence of C. trachomatis at baseline and 7 months; time to treatment; acceptability of TnT.\ud \ud Methods\ud Participants completed questionnaires and provided genitourinary samples at baseline and 7 months. Participants were informed that baseline samples would not be tested for 7 months and were advised to get screened independently. Colleges were randomly allocated 1:1 to intervention (TnT) or control (no TnT).\ud \ud One month and 4 months post recruitment, participants at intervention colleges were texted invitations for on-site free C. trachomatis tests. A purposive sample of students who did/did not attend for screening were interviewed (n = 26).\ud \ud Results\ud Five hundred and nine sexually active students were recruited: median age 17.9 years, 47% male, 50% black ethnicity, 55% reporting two or more sexual partners in the previous year. TnT uptake was 13% (33/259; 95% CI 8.9–17.4%) at 1 month and 10% (26/259; 6.7–14.4%) at 4 months with overall C. trachomatis positivity 5.1% (3/59; 1.1–14.2%). Follow-up at 7 months was 62% (317/509) for questionnaires and 52% (264/509) for samples. C. trachomatis prevalence was 6.2% (31/503) at baseline and 6.1% (16/264) at 7 months. Median time from test to treatment was 15 h. Interviews suggested low test uptake was associated with not feeling at risk, perceptions of stigma, and little knowledge of sexually transmitted infections (STIs).\ud \ud Conclusions\ud Despite high C. trachomatis rates at baseline and follow-up, uptake of testing was low. Like many countries, England urgently needs better sex education, including making STI testing routine/normal.\ud \ud Trial registration ISRCTN58038795
Databáze: OpenAIRE
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