HUMAN SERUM AND PLASMA INCREASE MOUSE MORTALITY IN STAPHYLOCOCCUS AUREUS INTRAPERITONEAL INFECTION
| Autor: | F. Espersen, I. Clemmensen, J. M. Rhodes, K. Jensen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Virulence Peritonitis Biology medicine.disease_cause Fibrinogen Microbiology Mice medicine Animals Humans Mice Inbred C3H General Immunology and Microbiology Strain (chemistry) General Medicine Staphylococcal Infections Blood Physiological Phenomena biology.organism_classification Fibronectins Fibronectin Staphylococcus aureus Human plasma biology.protein Female Bacteria medicine.drug |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series B: Microbiology. :305-310 |
| ISSN: | 0108-0180 |
| Popis: | The influence of human plasma, serum, purified fibrinogen, and fibronectin on Staphylococcus aureus intraperitoneal infection in non-immune mice was studied. Mouse mortality was used as a measure of staphylococcal virulence. Both human plasma and serum were shown to enhance the virulence of S.aureus strain E 2371 and strain E 2476 when added to the bacteria before challenge. This effect of serum was unaffected by storage for 24 h at 37 degrees C or complement-inactivation for 1 h at 56 degrees C. Purified fibrinogen and fibronectin did not influence the S. aureus virulence. It is suggested that the effects of plasma and serum described here might play a role in the establishment of S.aureus infections in humans. |
| Databáze: | OpenAIRE |
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