MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum
| Autor: | Xavier Langlois, Jean-Marc Taymans, Josée E. Leysen, Anne Simone Josephine Lesage, Catarina Cruz |
|---|---|
| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Gs alpha subunit Forskolin Dose-Response Relationship Drug General Neuroscience ADCY9 Biology Corpus Striatum ADCY10 Rats Adenylyl cyclase chemistry.chemical_compound Endocrinology Metabotropic receptor chemistry Internal medicine medicine Animals Dizocilpine Maleate Rats Wistar RGS Proteins RGS2 Adenylyl Cyclases Ionotropic effect |
| Zdroj: | Neuroreport, 16(2), 159-162. Lippincott Williams and Wilkins Ltd. Taymans, J M, Cruz, C, Lesage, A S, Leysen, J E M F & Langlois, X 2005, ' MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum ', Neuroreport, vol. 16, no. 2, pp. 159-162 . https://doi.org/10.1097/00001756-200502080-00018 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200502080-00018 |
| Popis: | The present report examines the eiects of acute NMDA antagonism on Regulator of G Protein Signaling 2 (RGS2) expression and adenylyl cyclase sensitivity in the rat striatum. MK- 801and phencyclidine rapidly down-regulate RGS2 mRNA. The down-regulation of RGS2 by MK- 801 was dose dependent and transient. Because previous reports showed that RGS2 attenuates activity of adenylyl cyclase, RGS2 protein level and sensitivity of adenylyl cyclase to forskolin was tested 2 h after administration of MK- 801 (1mg/kg). In striatal membranes of these rats, RGS2 protein level was 17% lower and forskolin-stimulated cAMP production 38% higher than in controls. These ¢ndings reveal a cross-talk between NMDA receptors and adenylyl cyclase and suggest a general cross-talk mechanism by which RGS proteins transcriptionally regulated by ionotropic receptors can alter signaling properties of metabotropic receptors. NeuroReport 16:159^162 � c 2005 Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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