Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants
| Autor: | Markku Mäki, Harri Sievänen, A L Kuusela, M C Backström, Anna-Maija Koivisto, Kouri T, R Mäki, R. S. Ikonen |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Bone density Drug Administration Schedule Absorptiometry Photon Bone Density Internal medicine 25-Hydroxyvitamin D 2 Vitamin D and neurology Humans Medicine Vitamin D Bone mineral business.industry Infant Newborn Obstetrics and Gynecology Gestational age Original Articles General Medicine Effective dose (pharmacology) Endocrinology Dietary Supplements Pediatrics Perinatology and Child Health Alkaline phosphatase business Infant Premature Hormone |
| Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 80:F161-F166 |
| ISSN: | 1468-2052 1359-2998 |
| DOI: | 10.1136/fn.80.3.f161 |
| Popis: | AIMS—To test the hypothesis that a vitamin D dose of 200 IU/kg, maximum 400 IU/day, given to preterm infants will maintain normal vitamin D status and will result in as high a bone mineral density as that attained with the recommended dose of 960 IU/day. METHODS—Thirty nine infants of fewer than 33 weeks of gestational age were randomly allocated to receive vitamin D 200 IU/kg of body weight/day up to a maximum of 400 IU/day or 960 IU/day until 3months old. Vitamin D metabolites, bone mineral content and density were determined by dual energy x-ray absorptiometry, and plasma ionised calcium, plasma alkaline phosphatase, and intact parahormone measurements were used to evaluate outcomes. RESULTS—The 25 hydroxy vitamin D concentrations tended to be higher in infants receiving 960 IU/day, but the differences did not reach significance at any age. There was no difference between the infants receiving low or high vitamin D dose in bone mineral content nor in bone mineral density at 3 and 6 months corrected age, even after taking potential risk factors into account. CONCLUSIONS—A vitamin D dose of 200 IU/kg of body weight/day up to a maximum of 400 IU/day maintains normal vitamin D status and as good a bone mineral accretion as the previously recommended higher dose of 960 IU/day. Vitamin D is a potent hormone which affects organs other than bone and should not be given in excess to preterm infants. |
| Databáze: | OpenAIRE |
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