Screening of wood/forest and vine by-products as sources of new drugs for sustainable strategies to control fusarium graminearum and the production of mycotoxins
| Autor: | MONTIBUS, Mathilde, VITRAC, Xavier, COMA, Veronique, LORON, Anne, LORON, A., PINSON-GADAIS, Laetitia, FERRER, Nathalie, VERDAL-BONNIN, Marie-Noëlle, GABASTON, Julien, WAFFO TEGUO, Pierre, RICHARD-FORGET, Florence, ATANASOVA-PENICHON, Vessela |
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| Přispěvatelé: | Institut Technologique Forêt Cellulose Bois-construction Ameublement (FCBA), Laboratoire PHENOBIO SAS, Partenaires INRAE, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 2 LCPO : Biopolymers & Bio-sourced Polymers, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Unité de recherche Mycologie et Sécurité des Aliments (MycSA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Recherche Oenologie [Villenave d'Ornon], Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-11-INBS-0010,METABOHUB,Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation(2011) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Fusarium
Vine [SDV]Life Sciences [q-bio] Trichothecene Pharmaceutical Science Wine Biology Forests ecological strategies Article Analytical Chemistry natural extracts Crop lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Vitis Physical and Theoretical Chemistry Mycotoxin Fusarium graminearum 030304 developmental biology 2. Zero hunger 0303 health sciences biofungicides 030306 microbiology business.industry Plant Extracts Organic Chemistry type B trichothecenes Pine sawdust food and beverages Water extraction Mycotoxins biology.organism_classification Wood Agronomy chemistry Pharmaceutical Preparations 13. Climate action Chemistry (miscellaneous) Agriculture [SDE]Environmental Sciences Molecular Medicine business |
| Zdroj: | Molecules Molecules, MDPI, 2021, 26 (2), pp.1-18. ⟨10.3390/molecules26020405⟩ Volume 26 Issue 2 Molecules, Vol 26, Iss 405, p 405 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26020405⟩ |
| Popis: | Fusarium graminearum is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by F. graminearum. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by F. graminearum. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling F. graminearum and its production of mycotoxins. |
| Databáze: | OpenAIRE |
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