The Role of Mixed Micelles in Drug Delivery. I. Solubilization
| Autor: | J. S. Dangi, S. P. Vyas, V. K. Dixit |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chromatography Chemistry Precipitation (chemistry) Organic Chemistry SODIUM DESOXYCHOLATE technology industry and agriculture Pharmaceutical Science Salt (chemistry) macromolecular substances bacterial infections and mycoses Micelle Dosage form Drug Delivery Systems Solubility Solubilization Amphotericin B Drug Discovery Drug delivery Thermodynamics lipids (amino acids peptides and proteins) Micelles |
| Zdroj: | Drug Development and Industrial Pharmacy. 24:681-684 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639049809082372 |
| Popis: | The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed micelles and it was also noted that mixed micellar systems are thermodynamically stable relative to micellar systems. It was observed that the degradation or precipitation of AmB was significantly reduced when stored at 8 degrees C. The mixed micellar systems composed of sodium desoxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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