Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report
| Autor: | Enrico Iemoli, Ernesto Longoni, Chiara Molteni, Alessandro Pandolfo, Marco Franzetti, Stefania Piconi, Ugo Pozzetti, Valentina Ormas, Paolo Faccioli, Manuela Carugati, Gioacchino Castaldo |
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| Rok vydání: | 2020 |
| Předmět: |
Cytokine-release syndrome
0301 basic medicine Microbiology (medical) Coronavirus disease 2019 (COVID-19) medicine.drug_class 030106 microbiology Remdesivir lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Medicine lcsh:RC109-216 030212 general & internal medicine Anakinra business.industry General Medicine medicine.disease Receptor antagonist Interleukin-1 receptor antagonist Cytokine release syndrome Infectious Diseases Interleukin 1 receptor antagonist Respiratory failure Tolerability Macrophage activation syndrome Immunology Novel coronavirus disease 2019 (COVID-19) business medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 97, Iss, Pp 215-218 (2020) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2020.05.050 |
| Popis: | We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection. |
| Databáze: | OpenAIRE |
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