Degradable Polymers and Nanoparticles Built from Salicylic Acid
| Autor: | M. Saeed Akkad, Christopher J. Serpell |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
Polymers medicine.medical_treatment Nanoparticle Biocompatible Materials 02 engineering and technology Targeted therapy 03 medical and health sciences chemistry.chemical_compound Hydrolysis 0302 clinical medicine Materials Chemistry medicine Humans Moiety Particle Size chemistry.chemical_classification Aspirin Organic Chemistry Polymer 021001 nanoscience & nanotechnology Biodegradable polymer Combinatorial chemistry chemistry 030220 oncology & carcinogenesis Nanoparticles Salicylic Acid 0210 nano-technology Salicylic acid medicine.drug |
| Zdroj: | Macromolecular Rapid Communications. 39:1800182 |
| ISSN: | 1022-1336 |
| Popis: | As more evidence emerges supporting the possibility that non-steroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management in certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumours. The primary disadvantage so far has been in use of non-therapeutic polymeric backbones that constitute the majority of the therapeutic particle’s size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. In this work, we demonstrate the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through formation of nanostructures. |
| Databáze: | OpenAIRE |
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