Fluorescence image-guided neurosurgery
| Autor: | Sadao Kaneko, Muftah S Eljamel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030103 biophysics Cancer Research medicine.medical_specialty Meningioma 03 medical and health sciences 0302 clinical medicine Glioma medicine Overall survival Humans Image guidance Tumor marker business.industry Brain Neoplasms Optical Imaging Image guided neurosurgery General Medicine medicine.disease Gross Total Resection Treatment Outcome Oncology Surgery Computer-Assisted Neurosurgery Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | Future oncology (London, England). 13(26) |
| ISSN: | 1744-8301 |
| Popis: | Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively. The differences between ALA-fluorescence image-guided neurosurgery (FIGS) and FLCN-FIGS in HGG were not statistically significant. However, the cost per quality added life years was US$16,218 and US$3181 for ALA-FIGS and FLCN-FIGS, respectively. Therefore, FIGS provided a reliable intraoperative tumor marker. Both ALA- and FLCN-FIGS significantly improved GTR and were cost-effective. |
| Databáze: | OpenAIRE |
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