Early versus later onset childhood-onset systemic lupus erythematosus: Clinical features, treatment and outcome
| Autor: | Joyce Hui-Yuen, Catherine M. Avitabile, Deborah M. Levy, Andrew H. Eichenfield, Philip Kahn, Lisa F. Imundo |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Cyclophosphamide Anti-Inflammatory Agents Kaplan-Meier Estimate Intensive Care Units Pediatric Severity of Illness Index Cohort Studies Rheumatology Prednisone Severity of illness Ethnicity medicine Humans Lupus Erythematosus Systemic In patient Age of Onset Child Retrospective Studies Lupus erythematosus business.industry Retrospective cohort study medicine.disease Treatment Outcome Disease Progression Female Kidney Diseases Age of onset business Immunosuppressive Agents medicine.drug Cohort study |
| Zdroj: | Lupus. 20:952-959 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203311403022 |
| Popis: | The objective of the study was to compare clinical features, treatment and disease outcome in patients with early versus later onset of childhood-onset systemic lupus erythematosus (cSLE). A retrospective matched cohort study of cSLE patients diagnosed between 1988 and 2008 and followed for a minimum of one year was conducted. Thirty-four pre-pubertal cSLE patients with disease onset prior to their 12th birthday were matched by ethnicity and year of diagnosis to 34 pubertal cSLE patients. The most common criteria at diagnosis in both groups were malar rash, arthritis, hematologic manifestations, and renal disease. After a mean follow-up of more than six years, a similar proportion of patients in the two groups were still prescribed corticosteroids (47% and 41%); patients in the early onset group required a significantly higher daily dose (0.6 mg/kg prednisone-equivalent versus 0.2 mg/kg, p |
| Databáze: | OpenAIRE |
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