Rotavirus and illness severity in children presenting with acute gastroenteritis at the primary care out-of-hours service
| Autor: | Wolters, Pien, Holtman, G. A, Weghorst, A. A. H, Knoester, M., Berger, M. Y. |
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| Přispěvatelé: | Life Course Epidemiology (LCE) |
| Rok vydání: | 2021 |
| Předmět: |
Male
Rotavirus Medicine (General) Primary Health Care Patient Acuity faeces/virology Infant Gastroenteritis/epidemiology gastroenteritis/virology Gastroenteritis paediatrics primary care R5-920 after-hours care Child Preschool Humans Original Article Prospective Studies Preschool Child Family Practice Research Article |
| Zdroj: | European Journal of General Practice, Vol 27, Iss 1, Pp 346-353 (2021) The European journal of general practice, 27(1), 346-353. TAYLOR & FRANCIS LTD The European Journal of General Practice article-version (VoR) Version of Record |
| ISSN: | 1751-1402 1381-4788 |
| Popis: | BACKGROUND: Rotavirus is a common cause of acute gastroenteritis in young children in the Netherlands, where rotavirus vaccination has not yet been implemented.OBJECTIVES: To evaluate a difference in illness severity course depending on the presence of rotavirus infection and assess the prevalence of viruses and the referral rate in children with acute gastroenteritis.METHODS: A prospective cohort of children aged 6 months to 6 years presenting with acute gastroenteritis to a primary care out-of-hours service from October 2016 to March 2018. Faeces were sampled and sent to a laboratory where viral pathogens were identified and quantified by real-time polymerase chain reaction. Severe course of acute gastroenteritis was defined as a Modified Vesikari Score of ≥11. In addition, we assessed referral rates. Chi-square tests were used to evaluate differences between groups.RESULTS: We included 75 children (34 boys) with a median age of 1.5 years (interquartile range, 0.9-2.0 years). The prevalence of rotavirus was 65.3% (95% confidence interval, 53.5-76.0) with a median cycle threshold of 16.0. Severe course of acute gastroenteritis was present in 31 of 71 children (4 were lost to follow-up). Those with rotavirus (20/47) did not have a severe course more often than those without (11/24): odds ratio, 0.88 (95% confidence interval, 0.33-2.36). Referral rates were comparable for rotavirus (15.2%) and non-rotavirus (14.3%).CONCLUSION: In out-of-hours primary care, rotavirus is common but not associated with increased severity and higher referral rates in children with acute gastroenteritis. |
| Databáze: | OpenAIRE |
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