The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine
| Autor: | M.B. Ketkar, Gerd Reznik, Sabine Dickhaus, U. Green |
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| Rok vydání: | 1977 |
| Předmět: |
Nasal cavity
Larynx Cancer Research Pathology medicine.medical_specialty Nitrosamines Esophageal Neoplasms Nose Neoplasms Mice Inbred Strains Mice Internal medicine Cricetinae otorhinolaryngologic diseases medicine Vascular Neoplasm Animals Esophagus Laryngeal Neoplasms Carcinogen Hematology business.industry Pharynx Bronchial Neoplasms Liver Neoplasms General Medicine Neoplasms Experimental respiratory system Respiratory Tract Neoplasms stomatognathic diseases medicine.anatomical_structure Oncology Female Tracheal Neoplasms business Respiratory tract |
| Zdroj: | Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. 90(3) |
| ISSN: | 0084-5353 |
| Popis: | Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration. The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi. Treatment with both substances additionally resulted in vascular neoplasms of the liver, while DPN only caused tumors in the pharynx, esophagus and forestomach. |
| Databáze: | OpenAIRE |
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