Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
| Autor: | Baomin Fan, Haitao Xiao, Zhaoxiang Bian, Lidan Zhong, Ze Si Lin, Chengyuan Lin, Tao Huang, Huai Xue Mu, Ling Zhao, Guang Zhi Zeng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Indoles Interleukin-1beta Pharmaceutical Science Pharmacology Kynurenic Acid Inflammatory bowel disease Analytical Chemistry magnolol inflammation ulcerative colitis tryptophan metabolites Mice chemistry.chemical_compound Kynurenic acid Drug Discovery biology Dextran Sulfate Colitis Ulcerative colitis Magnolol Biphenyl compound Biochemistry Chemistry (miscellaneous) Myeloperoxidase Molecular Medicine Lignans Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry medicine Animals Physical and Theoretical Chemistry Indoleacetic Acids Interleukin-6 Tumor Necrosis Factor-alpha Biphenyl Compounds Organic Chemistry Polyphenols biology.organism_classification medicine.disease digestive system diseases Mice Inbred C57BL Magnolia officinalis 030104 developmental biology chemistry biology.protein |
| Zdroj: | Molecules; Volume 22; Issue 7; Pages: 1218 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 22, Iss 7, p 1218 (2017) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules22071218 |
| Popis: | Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation. |
| Databáze: | OpenAIRE |
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