Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

Autor: Vincent W. V. Jaddoe, Deirdre M. Murray, Juha Pekkanen, Anne M. Karvonen, Martine Vrijheid, Kinga Polańska, Oleksandr Zvinchuk, Johanna Mäkelä, Louise C. Kenny, Costanza Pizzi, Adriette J. J. M. Oostvogels, Debbie A Lawlor, Elisabeth Thiering, Sara Farchi, Bernadeta Patro Golab, Ellis Voerman, Sheryl L. Rifas-Shiman, George Moschonis, Rae-Chi Huang, Suzanne Tough, Camilla Stoltenberg, John Wright, Jane West, Irina Lehmann, Wojciech Hanke, Leda Chatzi, Hanna Lagström, Henrique Barros, Keith M. Godfrey, Graham Devereux, Barbara Heude, Emily Oken, Lorenzo Richiardi, Francesco Forastiere, Tomas Trnovec, Andrea von Berg, Cécile Chevrier, Ellen A. Nohr, Maria Pia Fantini, Sheila McDonald, Carol Ní Chaoimh, Tanja G. M. Vrijkotte, Maties Torrent, Davide Gori, Anna Bergström, Anne-Marie Nybo Andersen, Nathalie Costet, Marie-Aline Charles, Veit Grote, Lenie van Rossem, Alet H. Wijga, Daniel O. Hryhorczuk, Yannis Manios, Trevor A. Mori, Monique Mommers, Renata Majewska, John Mehegan, Hazel Inskip, Romy Gaillard, Camilla Schmidt Morgen, George P. Chrousos, Thorkild I. A. Sørensen, Pilar Amiano, Eleni Papadopoulou, Nina Iszatt, Sarah Crozier, Carel Thijs, Irva Hertz-Picciotto, Sandra Ekström, Leanne K. Küpers, Ana Cristina Santos, Ferran Ballester, Fionnuala M. McAuliffe, Marie Standl, Luca Ronfani, Merete Eggesbø, Eva Corpeleijn, Agnieszka Pac, Berthold Koletzko, Vagelis Georgiu, Susana Santos, Daniela Porta, Per Magnus, Steve Turner
Přispěvatelé: Ma, Ronald CW, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Keck School of Medicine [Los Angeles], University of Southern California (USC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Azienda Sanitaria Locale [ROMA] (ASL), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Voerman, Elli, Santos, Susana, Patro Golab, Bernadeta, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P., Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vageli, Godfrey, Keith M., Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M., Kenny, Louise C., Koletzko, Berthold, Küpers, Leanne K., Lagström, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yanni, McAuliffe, Fionnuala M., McDonald, Sheila W., Mehegan, John, Mommers, Monique, Morgen, Camilla S., Mori, Trevor A., Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nohr, Ellen A., Nybo Andersen, Anne-Marie, Oken, Emily, Oostvogels, Adriëtte J J M, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L., Ronfani, Luca, Santos, Ana C., Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Matie, Tough, Suzanne C., Trnovec, Toma, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G M, West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild I A, Lawlor, Debbie A., Gaillard, Romy, Jaddoe, Vincent W V, Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Nofer Institute of Occupational Medicine, ARD - Amsterdam Reproduction and Development, Public and occupational health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Veterinary Biosciences, Department of Public Health, University of Helsinki, Clinicum
Rok vydání: 2019
Předmět:
Data Analysis
embarazo
Maternal Health
Blood Pressure
CHILDREN
Weight Gain
Cardiovascular
Vascular Medicine
Body Mass Index
0302 clinical medicine
Endocrinology
Pregnancy
Medicine
Mass index
estudios de cohortes
Cancer
030219 obstetrics & reproductive medicine
Statistics
WOMEN
ta3141
General Medicine
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Gestation
HEALTH
INTERVENTION
Childhood Obesity
Endocrine Disorders
03 medical and health sciences
Hypertensive Disorders in Pregnancy
Clinical Research
Diabetes Mellitus
Humans
Gestational Diabetes
Statistical Methods
Individual participant data
Prevention
Australia
Biology and Life Sciences
Odds ratio
medicine.disease
Obesity
Generic health relevance
Body mass index
Mathematics
Demography
Pediatric Obesity
Nutrition and Disease
Physiology
humanos
Reproductive health and childbirth
030204 cardiovascular system & hematology
Overweight
Medical and Health Sciences
Oral and gastrointestinal
Cohort Studies
Mathematical and Statistical Techniques
Risk Factors
Voeding en Ziekte
OFFSPRING OBESITY
Medicine and Health Sciences
030212 general & internal medicine
Childhood obesity
2. Zero hunger
Pediatric
sobrepeso
Medicine (all)
Obstetrics and Gynecology
Metaanalysis
3142 Public health care science
environmental and occupational health
Gestational Weight Gain
obesidad pediátrica
Europe
Stroke
PREGNANCY
Physiological Parameters
gestational weight gain
pregnancy
obesity
Hypertension
Female
medicine.symptom
Research Article
BIRTH
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Research and Analysis Methods
General & Internal Medicine
factores de riesgo
Life Science
Metabolic and endocrine
Nutrition
business.industry
índice de masa corporal
Body Weight
3121 General medicine
internal medicine and other clinical medicine
Metabolic Disorders
North America
Women's Health
business
Maternal body
Gestiational diabetes
Weight gain
Zdroj: PLOS Medicine
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS medicine, vol 16, iss 2
Voerman, E, Santos, S, Golab, B P, Amiano, P, Ballester, F, Barros, H, Bergstrom, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costet, N, Crozier, S, Devereux, G, Eggesbo, M, Ekstrom, S, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hryhorczuk, D, Huang, R-C, Inskip, H, Iszatt, N, Karvonen, A M, Kenny, L C, Koletzko, B, Kupers, L K, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Mommers, M, Morgen, C S, Mori, T A, Moschonis, G, Murray, D, Chaoimh, C N, Nohr, E A, Andersen, A-M N, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Ronfani, L, Santos, A C, Standl, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, Van Rossem, L, Von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood : An individual participant data meta-analysis ', PLoS Medicine, vol. 16, no. 2 . https://doi.org/10.1371/journal.pmed.1002744
PLOS Medicine 16 (2019) 2
PLoS Medicine
PLoS Medicine, 2019, 16 (2), pp.e1002744. ⟨10.1371/journal.pmed.1002744⟩
PLOS MEDICINE
r-FISABIO. Repositorio Institucional de Producción Científica
PLoS Med. 16:e1002744 (2019)
PLoS Medicine, Public Library of Science, 2019, 16 (2), pp.e1002744. ⟨10.1371/journal.pmed.1002744⟩
PLOS MEDICINE, 16(2):e1002744. PUBLIC LIBRARY SCIENCE
Voerman, E, Santos, S, Patro Golab, B, Amiano, P, Ballester, F, Barros, H, Bergström, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costet, N, Crozier, S, Devereux, G, Eggesbø, M, Ekström, S, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hryhorczuk, D, Huang, R-C, Inskip, H, Iszatt, N, Karvonen, A M, Kenny, L C, Koletzko, B, Küpers, L K, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Mommers, M, Morgen, C S, Mori, T A, Moschonis, G, Murray, D, Chaoimh, C N, Nohr, E A, Nybo Andersen, A-M, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Ronfani, L, Santos, A C, Standl, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood : An individual participant data meta-analysis ', PLoS Medicine, vol. 16, no. 2, e1002744 . https://doi.org/10.1371/journal.pmed.1002744
PLOS Medicine, 16(2):1002744. Public Library of Science
PLoS medicine
PLoS Medicine, Vol 16, Iss 2, p e1002744 (2019)
PLoS medicine, 16(2). Public Library of Science
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
PLOS Medicine, 16(2), e1002744-e1002744
ISSN: 1549-1676
1549-1277
DOI: 10.1371/journal.pmed.1002744
Popis: Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0–5.0 years), mid (5.0–10.0 years) and late childhood (10.0–18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain ranged from 10.2% to 21.6%. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). Limitations of this study include the self-report of maternal BMI and gestational weight gain for some of the cohorts, and the potential of residual confounding. Also, as this study only included participants from Europe, North America, and Australia, results need to be interpreted with caution with respect to other populations. Conclusions In this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.
Vincent Jaddoe and colleagues report that a high BMI before pregnancy, rather than excessive gestational weight gain, is more likely to contribute to childhood obesity.
Author summary Why was this study done? Maternal pre-pregnancy obesity and excessive gestational weight gain are important risk factors of various pregnancy and birth complications. An accumulating body of evidence suggests that maternal obesity and excessive gestational weight gain also have persistent effects on offspring fat development. It is not clear whether these effects exist across the full ranges of maternal pre-pregnancy body mass index and gestational weight gain, what their combined effects are, and what the population impact of these effects is. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 162,129 mothers and their children from 37 pregnancy and birth cohorts from Europe, North America, and Australia to assess the separate and combined associations of maternal pre-pregnancy body mass index and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. We observed not only that maternal pre-pregnancy overweight and obesity were associated with an increased risk of childhood overweight/obesity, but that this risk increased gradually over the full range of maternal BMI. Similarly, the risk of childhood overweight/obesity increased across the full range of gestational weight gain. We estimated that 21.7% to 41.7% of childhood overweight/obesity prevalence could be attributed to maternal overweight and obesity together, whereas 11.4% to 19.2% could be attributed to excessive gestational weight gain. The additional effect of excessive gestational weight gain on the risk of childhood overweight/obesity was small among women who are already overweight or obese before pregnancy. What do these findings mean? Maternal pre-pregnancy BMI and, to a smaller extent, gestational weight gain are important modifiable risk factors of childhood overweight/obesity with considerable population impact. Future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight status during pregnancy.
Databáze: OpenAIRE
Externí odkaz: