Survey of antiretroviral therapy adherence and predictors of poor adherence among HIV patients in a tertiary institution in Nigeria
| Autor: | Tobiloba C. Elebiyo, Opeyemi Ezekiel Ojo, Joseph O Fadare, Adekunle Olatayo Adeoti, Mobolaji Usman Dada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-HIV Agents 030231 tropical medicine Nigeria HIV Infections CD4 count Anxiety Logistic regression Medication Adherence 03 medical and health sciences 0302 clinical medicine Internal medicine Surveys and Questionnaires medicine Humans 030212 general & internal medicine Depression (differential diagnoses) business.industry Depression Research General Medicine Middle Aged medicine.disease CD4 Lymphocyte Count predictors Cross-Sectional Studies Spouse Adherence Serodiscordant HIV/AIDS Observational study Female medicine.symptom business Viral load Anxiety disorder mental health |
| Zdroj: | The Pan African Medical Journal |
| ISSN: | 1937-8688 |
| Popis: | Introduction Adherence is vital to effective antiretroviral therapy (ART) for reducing viral load and HIV/AIDS-related morbidity and mortality. This study was aimed at evaluating the adherence of HIV seropositive patients to ART in a tertiary institution in Nigeria. Methods A cross sectional observational study was conducted among 400 HIV seropositive patients. The study was carried out between December 2016 and February 2017 at the HIV clinic of the Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Results The mean age of the HIV patients was 42.2±9.5 years with a predominant female gender (Male:Female = 1:2.8). The median CD4 counts increased from 302.1±15.0cells/mm3 at diagnosis to 430.8±13.3cells/mm3 at the time of the study. Majority of participants were unaware of their spouses' HIV status (59.3%) while 32.5% of participants had a serodiscordant spouse. Poverty was a major challenge as 73.3% earned less than 140 dollars per month. Depressive symptoms, anxiety disorder and insomnia were also reported in 40.7%, 33.2% and 47.2% respectively. Poor adherence to ART was observed in almost 20% of the patients. Logistic regression indicated that predictors of poor adherence were depression, anxiety and low CD4 counts. Conclusion Adherence to anti-retroviral therapy was good amongst the majority of HIV seropositive patients. Depression, anxiety disorder and low CD4 count were however associated with poor adherence. This emphasizes the role of the psychology units as integral part of the HIV clinic to assist patients' adherence to anti-retroviral regimens. |
| Databáze: | OpenAIRE |
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