The evolution of diabetic ketoacidosis: An update of its etiology, pathogenesis and management
| Autor: | Abbas E. Kitabchi, Ebenezer Nyenwe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Diabetic ketoacidosis Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Disease Diabetic Ketoacidosis Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Diabetes Mellitus medicine Animals Humans 030212 general & internal medicine business.industry Incidence Insulin Incidence (epidemiology) medicine.disease Etiology business |
| Zdroj: | Metabolism. 65:507-521 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2015.12.007 |
| Popis: | The prognosis of diabetic ketoacidosis has undergone incredibly remarkable evolution since the discovery of insulin nearly a century ago. The incidence and economic burden of diabetic ketoacidosis have continued to rise but its mortality has decreased to less than 1% in good centers. Improved outcome is attributable to a better understanding of the pathophysiology of the disease and widespread application of treatment guidelines. In this review, we present the changes that have occurred over the years, highlighting the evidence behind the recommendations that have improved outcome. We begin with a discussion of the precipitants and pathogenesis of DKA as a prelude to understanding the rationale for the recommendations. A brief review of ketosis-prone type 2 diabetes, an update relating to the diagnosis of DKA and a future perspective are also provided. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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