Randomised single blind trial to compare the toxicity of subconjunctival gentamicin and cefuroxime in cataract surgery
| Autor: | D. J. Spalton, C. D. G. Jenkins, P. J. Mcdonnell |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Eye Hemorrhage
medicine.medical_specialty Eye disease medicine.medical_treatment Hyperemia Cataract Extraction Conjunctival Diseases Cellular and Molecular Neuroscience Endophthalmitis medicine Edema Humans Single-Blind Method Prospective Studies Observer Variation Cefuroxime Intraoperative Care business.industry Aminoglycoside Cataract surgery medicine.disease Sensory Systems Surgery Ophthalmology Anesthesia Toxicity Gentamicin Gentamicins business Conjunctiva Research Article medicine.drug |
| Zdroj: | British Journal of Ophthalmology. 74:734-738 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.74.12.734 |
| Popis: | Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p less than 0.001). Gentamicin is associated with more pain postoperatively (p less than 0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum. |
| Databáze: | OpenAIRE |
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