All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway
| Autor: | Mao Nie, Qian-Zhao Chen, Zi-Jun Meng, Liangjun Yin, Ruidong Li, Bai-Cheng He, Zhong-Liang Deng, Nian Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research p38 mitogen-activated protein kinases Cell Retinoic acid Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine neoplasms Oncogene organic chemicals Mesenchymal stem cell Cell cycle medicine.disease biological factors 030104 developmental biology medicine.anatomical_structure Oncology chemistry Apoptosis 030220 oncology & carcinogenesis Cancer research Osteosarcoma Corrigendum |
| Zdroj: | International Journal of Oncology |
| ISSN: | 1791-2423 1019-6439 |
| Popis: | Osteosarcoma (OS) is the most common malignant bone tumour and is considered to be a disease caused by a dysfunction in differentiation. Bone morphogenetic protein 9 (BMP9) is the most potent osteogenic factor in mesenchymal stem cells, but it cannot induce osteogenic differentiation in OS cells; this might be one of the determinants in the pathogenesis of OS. All-trans retinoic acid (ATRA) can induce osteogenic differentiation of OS cells and potentiate BMP9-induced osteogenesis in preadipocytes. However, the concomitant effect of ATRA and BMP9 in OS cells is unclear; therefore, in the present study, we focused on this topic. The results showed that BMP9 significantly promoted the proliferation of human OS 143B cells and did not induce osteogenic differentiation of cells in vitro (p |
| Databáze: | OpenAIRE |
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