Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering
| Autor: | Wei Cao, Wenchao Zhong, Mingjing Zhu, Gang Wu, Qingbin Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Chemistry
QH301-705.5 Cartilage Biomedical Engineering Biomaterial Treatment options Articular cartilage Chondrogenesis Article Cartilage tissue engineering Biomaterials Extracellular matrix medicine.anatomical_structure Chondroconductive Peptide medicine TA401-492 Chondroinductive Biology (General) Materials of engineering and construction. Mechanics of materials Biotechnology Biomedical engineering |
| Zdroj: | Zhu, M, Zhong, W, Cao, W, Zhang, Q & Wu, G 2022, ' Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering ', Bioactive Materials, vol. 9, pp. 221-238 . https://doi.org/10.1016/j.bioactmat.2021.07.004 Bioactive Materials, Vol 9, Iss, Pp 221-238 (2022) Bioactive Materials |
| DOI: | 10.1016/j.bioactmat.2021.07.004 |
| Popis: | The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth factors. In this review, we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. We also systematically compare their in-vitro and in-vivo efficacies in inducing chondrogenesis. Our vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering. Graphical abstract Image 1 Highlights • Chondroinductive/chondroconductive peptides and their-functionalized biomaterials are highly promising for cartilage tissue engineering. • In comparison with proteinous growth factors, peptides can be chemically synthesized with much higher efficiency, quantity and purity and can be easily modified to improve their functions and to conjugate to biomaterials. • Peptides can be divided into two categories: growth factor-derived and cell-cell adhesion molecule/ECM components-derived. • We summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. • Further research may focus on the evaluation, design and development of more potent chondroinductive peptides and their-functionalized biomaterials. Meanwhile, more systematic studies should be performed to investigate and optimize the in-vitro and in-vivo efficacies of chondroinductive/chondroconductive peptide-based biomaterials for cartilage tissue engineering. |
| Databáze: | OpenAIRE |
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