Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma
| Autor: | Ola Nabih, Amen H. Zaky, Rania Bakry, Mostafa E. Abdel-Wanis, Mahmoud Rezk, Dalia A. Elsers, Rania Hafez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Lymphoma B-Cell Tumor suppressor gene medicine.disease_cause Malignancy Pathology and Forensic Medicine Pathogenesis 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Biomarkers Tumor Humans Progression-free survival Aged business.industry General Medicine Middle Aged medicine.disease Prognosis Progression-Free Survival Lymphoma 030104 developmental biology medicine.anatomical_structure Oncology Cyclooxygenase 2 030220 oncology & carcinogenesis Cancer research Female Bone marrow Tumor Suppressor Protein p53 business Carcinogenesis Diffuse large B-cell lymphoma |
| Zdroj: | Pathology oncology research : POR. 26(2) |
| ISSN: | 1532-2807 |
| Popis: | Cyclooxygenase-2 (COX-2) plays an important role in carcinogenesis, which catalyzes the conversion of arachidonic acid into prostaglandins. P53 is a tumor suppressor gene that contributes to apoptosis and cell cycle control. There is functional interaction between p53 and COX-2, which lead to abrogation of apoptosis and progression of malignancy. To assess the relationship between COX-2, p53 expression and the clinicopathololgic features in SLL and DLBCL. We immunohistochemically examined the expression of COX-2 and p53 in non-neoplastic lymphoid cells, lymph nodal low-grade (50 cases of SLL), intermediate and high-grade lymphomas (100 cases of DLBCL) and their corresponding bone marrow specimens. The expression of COX-2 and p53 was absent in the in non-neoplastic lymphoid cells. In contrast, their expression values increased progressively with the advancing grade of lymphoma (p |
| Databáze: | OpenAIRE |
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