Fast and pH-dependent release of domperidone from orally disintegrating tablets
| Autor: | Enas A Al-Ani, Shereen M. Assaf, Amjad M. Qandil |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Absorption (pharmacology)
Time Factors Drug Compounding Acrylic Resins Administration Oral Pharmaceutical Science Ph dependent Pharmacology Friability Excipients Delayed-Action Preparations Hardness Spectroscopy Fourier Transform Infrared medicine Dissolution testing Free drug Dissolution Calorimetry Differential Scanning Chemistry Povidone General Medicine Hydrogen-Ion Concentration Domperidone Thermogravimetry Dopamine Antagonists Tablets Nuclear chemistry medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. 18:897-905 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | There has been growing interest in orally disintegrating tablets (ODTs) during the last decade due to their better patient acceptance and compliance. Further, drug dissolution and absorption may be significantly improved. This work describes the preparation of fast and pH-dependent release ODTs for domperidone by direct compression using crospovidone as superdisintegrant. Solid dispersions of domperidone and Eudragit L100-55, at different weight ratios, were prepared and characterized by DSC, TGA, X-ray diffraction, and FTIR, which indicated the presence of drug-polymer interaction. Disintegration time, friability, and hardness of ODTs were evaluated. In vitro drug release in 0.1N HCl and in phosphate buffer (pH 5.8 and 6.8) was investigated. All domperidone ODTs had fast disintegration times (6 KP) and acceptable friability ( |
| Databáze: | OpenAIRE |
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