Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV Infection
| Autor: | Gustavo Reyes-Terán, Claudia Alvarado-de la Barrera, Fernando Antonio Silva-Sánchez, Ricardo Vega-Barrientos, Mónica Rodríguez, César Luna-Rivero |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology Future studies Fatal outcome business.industry Progressive multifocal leukoencephalopathy lcsh:R Human immunodeficiency virus (HIV) lcsh:Medicine Case Report General Medicine medicine.disease medicine.disease_cause chemistry.chemical_compound medicine.anatomical_structure Immune reconstitution inflammatory syndrome chemistry Internal medicine medicine Iris (anatomy) business Maraviroc |
| Zdroj: | Case Reports in Medicine, Vol 2014 (2014) Case Reports in Medicine |
| ISSN: | 1687-9635 1687-9627 |
| Popis: | Due to the lack of therapeutic options for patients with progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS), maraviroc has generated expectations among the medical community. However, we report a patient with advanced HIV infection, who developed PML-associated IRIS and had a fatal outcome despite the addition of maraviroc to suppressive ART. Future studies are required to define the therapeutic role of maraviroc in PML-associated IRIS and differentiate individuals who may benefit from maraviroc from those who may develop neurological deterioration. |
| Databáze: | OpenAIRE |
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