| Autor: |
Pedro Mario, Pan, João R, Sato, Marie-Laure, Paillère Martinot, Jean-Luc, Martinot, Eric, Artiges, Jani, Penttilä, Yvonne, Grimmer, Betteke M, van Noort, Andreas, Becker, Tobias, Banaschewski, Arun L W, Bokde, Sylvane, Desrivières, Herta, Flor, Hugh, Garavan, Bernd, Ittermann, Frauke, Nees, Dimitri, Papadopoulos Orfanos, Luise, Poustka, Juliane H, Fröhner, Robert, Whelan, Gunter, Schumann, Margaret L, Westwater, Christian, Grillon, Hugo, Cogo-Moreira, Argyris, Stringaris, Monique, Ernst |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
The American journal of psychiatry. 179(7) |
| ISSN: |
1535-7228 |
| Popis: |
Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium.iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups. Eleven regions of interest, key nodes of the reward system, were used to probe the reward network and calculate the connectivity strength of the VS within this network (VS connectivityHigher right VS connectivityThe connectivity strength of the VS within the reward network showed distinct patterns of association with depressive disorders and anhedonia from mid to late adolescence, suggesting that the role of this circuitry in depression changes with age. This study replicates, in an independent sample, the association between the VS and depression previously reported in younger adolescents. The findings suggest a role of VS connectivity |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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