Fabrication and In-Vivo Study of Micro-Colloidal Zanthoxylum acanthopodium-Loaded Bacterial Cellulose as a Burn Wound Dressing
| Autor: | Izabela Radecka, Syafruddin Ilyas, Tamrin Tamrin, Khatarina Meldawati Pasaribu, Ardiansyah Sembiring, Appealwan Altruistis Sarumaha, Saharman Gea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Polymers and Plastics Composite number 02 engineering and technology engineering.material wound dressing BC-MZA Article lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Colloid Zanthoxylum lcsh:Organic chemistry composite Fourier transform infrared spectroscopy Porosity 030304 developmental biology 0303 health sciences biology bacterial cellulose General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification MZA chemistry Bacterial cellulose engineering Biopolymer 0210 nano-technology Wound healing Nuclear chemistry |
| Zdroj: | Polymers, Vol 12, Iss 1436, p 1436 (2020) Polymers Volume 12 Issue 7 |
| ISSN: | 2073-4360 |
| Popis: | Bacterial cellulose (BC) is a biopolymer commonly used for wound dressing due to its high biocompatible properties either in-vitro or in-vivo. The three-dimensional fiber structure of BC becomes an advantage because it provides a template for the impregnation of materials in order to improve BC&rsquo s properties as a wound dressing, since BC has not displayed any bioactivity properties. In this study, micro-colloidal Zanthoxylum acanthopodium (MZA) fruit was loaded into BC fibers via an in-situ method. Z. acanthopodium is known to have anti-inflammatory, antioxidant and antimicrobial activities that can support BC to accelerate the wound healing process. The FTIR, XRD and SEM analysis results showed that the loading process of MZA and the composite fabrication were successfully carried out. The TGA test also showed that the presence of MZA in BC fibers decreased Tmax composite from BC, from 357.8 to 334.5 ° C for BC-MZA3. Other aspects, i.e., water content, porosity, hemocompatibility and histology studies, also showed that the composite could potentially be used as a wound dressing. |
| Databáze: | OpenAIRE |
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