DNA Damage in Stem Cells
| Autor: | Gwenola Manic, Lorenzo Galluzzi, Ilio Vitale, Ruggero De Maria, Guido Kroemer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pluripotent Stem Cells
0301 basic medicine DNA Repair DNA repair Cellular differentiation Biology Radiation Tolerance Immortal DNA strand hypothesis Genomic Instability 03 medical and health sciences stem cells Cancer stem cell Neoplasms Animals Humans Induced pluripotent stem cell Molecular Biology Embryonic Stem Cells Settore MED/06 - ONCOLOGIA MEDICA Genetic Drift Cell Biology Molecular biology Embryonic stem cell Cell biology Adult Stem Cells 030104 developmental biology Mutation Neoplastic Stem Cells Stem cell DNA Damage Adult stem cell |
| Zdroj: | Molecular Cell. 66:306-319 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2017.04.006 |
| Popis: | Both embryonic and adult stem cells are endowed with a superior capacity to prevent the accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells, which would be particularly detrimental to the whole organism. Inducible pluripotent stem cells also display a robust DNA damage response, but the stability of their genome is often conditioned by the mutational history of the cell population of origin, which constitutes an obstacle to clinical applications. Cancer stem cells are particularly tolerant to DNA damage and fail to undergo senescence or regulated cell death upon accumulation of genetic lesions. Such a resistance contributes to the genetic drift of evolving tumors as well as to their limited sensitivity to chemo- and radiotherapy. Here, we discuss the pathophysiological and therapeutic implications of the molecular pathways through which stem cells cope with DNA damage. |
| Databáze: | OpenAIRE |
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