Inflammasome: Its role in traumatic brain and spinal cord injury
| Autor: | Neda Khanlarkhani, Keywan Mortezaee, Adib Zendedel, Cordian Beyer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Inflammasomes Physiology Traumatic brain injury Interleukin-1beta Clinical Biochemistry Central nervous system Caspase 1 Poison control NLR Proteins 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic NLR Family Pyrin Domain-Containing 3 Protein medicine Humans Spinal cord injury Spinal Cord Injuries Neuroinflammation Adaptor Proteins Signal Transducing Neurons business.industry Interleukin-18 Pyroptosis Brain Inflammasome Cell Biology medicine.disease 030104 developmental biology medicine.anatomical_structure Immunology Apoptosis Regulatory Proteins business Neuroscience 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Journal of Cellular Physiology. 233:5160-5169 |
| ISSN: | 1097-4652 0021-9541 |
| Popis: | Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to neuropathological conditions which have in consequence the initiation of pro-inflammatory cytokine production. Neuroinflammation plays a key role in the secondary phase of both TBI and SCI after initial cell death. Activation of cytoplasmic inflammasome complexes is regarded as the essential step of neuroinflammation and a key trigger for neuronal death called pyroptosis. Inflammasome complexes are involved in activation of caspase-1 which catalyzes the cleavage of pro-interleukins into their active forms (including interleukin-18 [IL-18] and IL-1β). The focus of this article is to discuss the time-course and regulation of inflammasome assembly and activation during TBI and SCI and their targeting in designing therapeutic approaches. We particularly focus on the inflammasomes NLRP1 and NLRP3 which play a pivotal function during TBI and SCI in the central nervous system (CNS). |
| Databáze: | OpenAIRE |
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