Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats
| Autor: | Anne Virsolvy, Côme Pasqualin, Joanna Arthur-Ataam, Sylvain Richard, Bérengère Fromy, Azzouz Charrabi, Nicolas Jouy, Pierre Sicard, Kiao-Ling Liu, Saadia Eddahibi, Patrice Bideaux |
|---|---|
| Přispěvatelé: | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305 (LBTI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Signalisation et Transports Ioniques Membranaires (STIM), Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Phyco-Biotech, MORNET, Dominique, Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male arterial structure Aorta Thoracic 030204 cardiovascular system & hematology Rats Inbred WKY 0302 clinical medicine Rats Inbred SHR Thoracic aorta Aorta Nutrition and Dietetics biology Chemistry 3. Good health [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system spirulina Collagen Extracellular Matrix Degradation lcsh:Nutrition. Foods and food supply medicine.medical_specialty hypertension Nutritional Supplementation Biological Availability lcsh:TX341-641 Article vascular function 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine medicine.artery medicine Animals Arterial Pressure Fragmentation (cell biology) Antihypertensive Agents silicon medicine.disease Bioavailability Elastin Rats [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition 030104 developmental biology Endocrinology Blood pressure Dietary Supplements Arterial stiffness biology.protein [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science |
| Zdroj: | Nutrients Nutrients, MDPI, 2019, 11 (11), pp.2574. ⟨10.3390/nu11112574⟩ Volume 11 Issue 11 Nutrients, 2019, 11 (11), pp.2574. ⟨10.3390/nu11112574⟩ Nutrients, Vol 11, Iss 11, p 2574 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11112574⟩ |
| Popis: | International audience; Vascular aging is characterized by increase in arterial sti↵ness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply and bioavailability of silicon are often inadequate. Spirulina (Sp), micro algae have recognized nutritional properties and are able to incorporate minerals in a bioavailable form. We evaluated the e↵ects of nutritional supplementation with silicon-enriched spirulina (SpSi) on arterial system structure and function in hypertension. Experiments were performed on hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats supplemented with SpSi or Sp over a period of three months. Arterial pressure, vascular function and morphometric parameters of thoracic aorta were analyzed. SpSi supplementation lowered arterial pressure in SHR and minimized morphometric alterations induced by hypertension. Aortic wall thickness and elastic fibers fragmentation were partially reversed. Collagen and elastin levels were increased in association with extracellular matrix degradation decrease. Vascular reactivity was improved with better contractile and vasorelaxant responses to various agonists. No changes were observed in SHR supplemented with Sp. The beneficial e↵ects of SpSi supplementation evidenced here, may be attributable to Si enrichment and o↵er interesting opportunities to prevent cardiovascular risks. |
| Databáze: | OpenAIRE |
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