High dietary calcium to phosphorus ratio and alkali-forming potential as factors promoting silica urolithiasis in sheep
| Autor: | S R Stewart, R. J. Emerick, R H Pritchard |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Sheep Diseases chemistry.chemical_element Urine Alkalies Calcium Biology chemistry.chemical_compound Animal science Internal medicine Genetics medicine Animals Kidney Sheep Sodium bicarbonate Phosphorus General Medicine Silicon Dioxide Alkali metal Diet Calcium Dietary Endocrinology medicine.anatomical_structure chemistry Hay Urinary Calculi Animal Science and Zoology Ammonium chloride Food Science |
| Zdroj: | Journal of Animal Science. 68:498 |
| ISSN: | 0021-8812 |
| DOI: | 10.2527/1990.682498x |
| Popis: | Sheep were used to study factors previously found to promote silica urolithiasis in a rat model. In addition to high silica, these dietary factors included elevated calcium, a high calcium to phosphorus ratio and alkali-forming effects. Wether lambs had ad libitum access to a diet of 50% of grass hay and 50% ground oats plus supplement. Diet analysis was 3.4% total SiO2, .29% calcium, .25% phosphorus, 11.3% CP and 28% ADF. Treatments (40 lambs/treatment) consisted of a control (C), limestone to increase dietary calcium to .6% (L), L + 1% sodium bicarbonate (LS) and L + 1% ammonium chloride (LA). After a 91-d experimental period followed by a 56-d postexperimental finishing period, silica kidney deposits were found in all treatments, and SiO2 made up 74% to 97% of the urolithic ash. Kidney urolith incidences in the four treatments were C, 7/40; L, 12/40; LS, 20/40; and LA, 9/40. A higher urolith incidence in LS (LS vs C, P less than .05) and a trend toward a higher incidence in L (L vs C, P less than .2), accompanied by elevated urine pH (L = LS greater than C greater than LA, P less than .01), lend support to the concept that high-silica diets having high calcium to phosphorus ratios and alkali-forming potentials contribute to silica urolithiasis. |
| Databáze: | OpenAIRE |
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