T-2 Toxin-induced Toxicity in Pregnant Mice and Rats
| Autor: | Noriaki Ishigami, Kunio Doi, Shinya Sehata |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Peptidyl transferase
maternal toxicity Review medicine.disease_cause Catalysis Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound medicine Protein biosynthesis Cytotoxic T cell rat Physical and Theoretical Chemistry Mycotoxin Molecular Biology lcsh:QH301-705.5 Spectroscopy mouse biology DNA synthesis Toxin Organic Chemistry apoptosis RNA General Medicine fetal toxicity Molecular biology Computer Science Applications T-2 Toxin chemistry lcsh:Biology (General) lcsh:QD1-999 Apoptosis Immunology biology.protein |
| Zdroj: | International Journal of Molecular Sciences, Vol 9, Iss 11, Pp 2146-2158 (2008) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably secondary to the inhibition of protein synthesis. In addition, T-2 toxin is said to induce apoptosis in many types of cells bearing high proliferating activity. T-2 toxin readily passes the placenta and is distributed to embryo/fetal tissues, which include many component cells bearing high proliferating activity. This paper reviews the reported data related to T-2 toxin-induced maternal and fetal toxicities in pregnant mice and rats. The mechanisms of T-2 toxin-induced apoptosis in maternal and fetal tissues are also discussed in this paper. |
| Databáze: | OpenAIRE |
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