Seasonal variation in neurohormones, mood and sleep in patients with primary open angle glaucoma - implications of the ipRGC-system
| Autor: | Miriam Kolko, Henrik Lund-Andersen, Ida Hageman, Helle Østergaard Madsen, Klaus Martiny, Shakoor Ba-Ali |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Open angle glaucoma Physiology Glaucoma 030209 endocrinology & metabolism Audiology Melatonin 03 medical and health sciences 0302 clinical medicine Physiology (medical) Medicine Humans Circadian rhythm Neurotransmitter Agents business.industry Intrinsically photosensitive retinal ganglion cells medicine.disease Sleep in non-human animals Circadian Rhythm Mood Seasons business Neurohormones Sleep 030217 neurology & neurosurgery Glaucoma Open-Angle medicine.drug |
| Zdroj: | Chronobiology international. 38(10) |
| ISSN: | 1525-6073 |
| Popis: | Primary open angle glaucoma is associated with an increased risk of mood and sleep disorders. These adversities have been suggested to relate to a disrupted function of the intrinsically photosensitive retinal ganglion cells (ipRGCs). The ipRGCs are key components in the nonvisual photoreceptive system that mediates light effects on mood, sleep and circadian rhythm. We assessed the diurnal hormone levels, pupillary responses and mood and sleep under seasons with different photoperiods in 24 patients with glaucoma and 24 age- and sex-matched healthy controls to investigate responses to naturalistic seasonal changes in daylight. The patients had moderate-to-advanced glaucoma with substantial visual field defects and reductions in the ipRGC-mediated pupillary responses ( |
| Databáze: | OpenAIRE |
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